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FLASH GENE

Symbol

BTG4

contributors: mct/npt - updated : 02-09-2020

HGNC name	B-cell translocation gene 4
HGNC id	13862

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system ovary         male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial sensory olfactory

cell lineage	oocyte
cell lines
fluid/secretion

at STAGE

physiological period

embryo

cell cycle

cell cycle, interphase, G1

Text	preimplantation olfactory epithelium

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	conserved N-terminal domain spanning 104-106 AAs, a protein-protein interaction module, which is capable of binding to DNA-binding transcription factors as well as the paralogues CNOT7 (human Caf1/Caf1a) and CNOT8 (human Pop2/Calif/Caf1b), two deadenylase subunits of the Ccr4-Not complex (Winkler 2010)
	potential phosphorylation sites for protein kinase C
	casein kinase 2
	two conserved regions—the N-terminal BTG domain that contains the Box-A and Box-B motifs
	C-terminal regions are less conserved and appear to mediate protein-protein interactions that are unique to each family member

HOMOLOGY

interspecies

ortholog to murine Pc3b

Homologene

FAMILY

Tob/TBG1 family of growth inhibitory gene

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	antiproliferative activity, being able to induce G(1) arrest
	implicated in transcription in the nucleus and cytoplasmic mRNA deadenylation and turnover (Winkler 2010)
	is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes
	is an essential regulator of metaphase II arrest
	BTG4-dependent pathway for controlling poly(A) tail length during meiosis with an unexpected role for mRNA deadenylation in preventing the spontaneous activation of eggs
	role of BTG4 in human early embryonic development

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

text	differentiation of olfactory epithelium (mouse

PATHWAY

metabolism

signaling

a component

complex of BTG4 and CNOT7, CNOT8 safeguards metaphase II arrest in mammalian eggs by deadenylating maternal mRNAs

INTERACTION

DNA

RNA

small molecule

protein	anti-proliferative activity of BTG1, BTG2, BTG3, BTG4, TOB1, TOB2 proteins is mediated through interactions with the CNOT7, CNOT8 deadenylase enzymes
	BTG4 is a novel TP53-regulated gene and probably functions as a tumor suppressor in lung and colorectal cancers
	BTG4 functions as an adaptor by recruiting the CCR4-NOT catalytic subunits CNOT7 and CNOT8, which are involved in mRNA decay

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ZCF1

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   significantly reduced in primary gastric cancer by hypermethylation but not in normal gastric tissues (Dong 2009) tumoral fusion       with POU2AF1 in t(11;13)(q23;q12) in chronic lymphocytic leukemia

Susceptibility

Variant & Polymorphism

Candidate gene	candidate tumor suppressor gene that is epigenetically silenced in the majority of gastric cancers (Dong 2009)
Marker
Therapy target

ANIMAL & CELL MODELS

	Btg4 null female mice produce morphologically normal oocytes that, due to the accumulation of maternal mRNAs, arrest at the one-cell stage after fertilization
	Btg4-null females produced morphologically normal oocytes but were infertile, owing to early developmental arrest