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FLASH GENE
Symbol BTG4 contributors: mct/npt - updated : 02-09-2020
HGNC name B-cell translocation gene 4
HGNC id 13862
DNA
TYPE functioning gene
STRUCTURE 44.81 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   transcription factor
text structure
  • BTG4 promoter contains binding sites for canonical transcription factors, such as Sp1, whereas its first intron contains two overlapped consensus TP53 binding sites
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1000 26 223 - Dong (2009)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary   
     male systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsensoryolfactory  
    cell lineage oocyte
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    cell cycle     cell cycle, interphase, G1
    Text preimplantation olfactory epithelium
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • conserved N-terminal domain spanning 104-106 AAs, a protein-protein interaction module, which is capable of binding to DNA-binding transcription factors as well as the paralogues CNOT7 (human Caf1/Caf1a) and CNOT8 (human Pop2/Calif/Caf1b), two deadenylase subunits of the Ccr4-Not complex (Winkler 2010)
  • potential phosphorylation sites for protein kinase C
  • casein kinase 2
  • two conserved regions—the N-terminal BTG domain that contains the Box-A and Box-B motifs
  • C-terminal regions are less conserved and appear to mediate protein-protein interactions that are unique to each family member
    • HOMOLOGY
    interspecies ortholog to murine Pc3b
    Homologene
    FAMILY
  • Tob/TBG1 family of growth inhibitory gene
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • antiproliferative activity, being able to induce G(1) arrest
  • implicated in transcription in the nucleus and cytoplasmic mRNA deadenylation and turnover (Winkler 2010)
  • is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes
  • is an essential regulator of metaphase II arrest
  • BTG4-dependent pathway for controlling poly(A) tail length during meiosis with an unexpected role for mRNA deadenylation in preventing the spontaneous activation of eggs
  • role of BTG4 in human early embryonic development
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    text differentiation of olfactory epithelium (mouse
    PATHWAY
    metabolism
    signaling
    a component
  • complex of BTG4 and CNOT7, CNOT8 safeguards metaphase II arrest in mammalian eggs by deadenylating maternal mRNAs
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • anti-proliferative activity of BTG1, BTG2, BTG3, BTG4, TOB1, TOB2 proteins is mediated through interactions with the CNOT7, CNOT8 deadenylase enzymes
  • BTG4 is a novel TP53-regulated gene and probably functions as a tumor suppressor in lung and colorectal cancers
  • BTG4 functions as an adaptor by recruiting the CCR4-NOT catalytic subunits CNOT7 and CNOT8, which are involved in mRNA decay
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ZCF1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    significantly reduced in primary gastric cancer by hypermethylation but not in normal gastric tissues (Dong 2009)
    tumoral fusion      
    with POU2AF1 in t(11;13)(q23;q12) in chronic lymphocytic leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate tumor suppressor gene that is epigenetically silenced in the majority of gastric cancers (Dong 2009)
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Btg4 null female mice produce morphologically normal oocytes that, due to the accumulation of maternal mRNAs, arrest at the one-cell stage after fertilization
  • Btg4-null females produced morphologically normal oocytes but were infertile, owing to early developmental arrest