protein
| homophilic, calcium dependent, cell cell interactions |
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interacting by its C terminus with the cytoskeleton via beta-catenin |
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interacts via an internal PDZ-binding site with the PDZ1 domain of the stereociliary protein harmonin, and potentially via a weaker binding of its C terminus with harmonin PDZ2 domain |
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EHD4 is a novel CDH23-interacting protein that could regulate CDH23 trafficking/localization in a calcium-sensitive manner) |
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interacting with USH1C (to connect stereocilia into a bundle) |
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interact in trans with PCDH15 homodimers to form a filament with structural similarity to tip links, in sensory hair cells |
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CDH23 and PCDH15 interact to form tip links, which gate mechanotransduction channels in hair cells of the inner ear |
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directly binds to the tail of myosin VIIa (MYO7A) |
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with harmonin and myosin VIIa bind to phosphorylated forms of phosphatidylinositol including phosphatidylinositol 4,5-bisphosphate |
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CNGA3 interacts with stereocilia tip-link CDH23 + exon 68 or alternatively with MYO7A, two proteins required for hair cell mechanotransduction |
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CDH23, PCDH15 bind tip-to-tip in a "handshake" mode that involves the EC1 and EC2 repeats ofCDH23, PCDH15 |
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interaction between CDH23 and CAMSAP3/Marshalin plays a vital role in hearing and vision, suggesting that CDH23-C is a CAMSAP3/Marshalin-binding protein that can modify MT networks indirectly through its interaction with CAMSAP3/Marshalin |