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FLASH GENE

Symbol

SCUBE1

contributors: mct/npt - updated : 13-01-2021

HGNC name	signal peptide, CUB domain, EGF-like 1
HGNC id	13441

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     may be, in the del 22q13 syndrome constitutional     --over   in acute coronary syndrome (ACS) and acute ischemic stroke (AIS), but not in chronic coronary artery disease (CAD) constitutional     --over   elevated levels of SCUBE1, a novel platelet activation marker, in primary hypertensive patients

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	biomarker of platelet activation in acute coronary syndrome (ACS) and acute ischemic stroke (AIS)
	is a novel platelet activation marker
	increased serum SCUBE1 concentrations have close relation to increasing severity and poor prognosis of intracerebral hemorrhage (ICH)
	plasma SCUBE1 measurement may have diagnostic, therapeutic, or prognostic value in testicular torsion (TT)
	SCUBE1 may be a promising biomarker for the early diagnosis of ovarian torsion (OT)
Therapy target
	System Type Disorder Pubmed blood coagulation   blockade of soluble SCUBE1 might represent a novel antithrombotic strategy blood coagulation   targeting theadhesive motifs of SCUBE1 is a potential anti-thrombotic strategy

ANIMAL & CELL MODELS

plasma deficiency of Sube1 diminished arterial thrombosis in mice and protected against lethal thromboembolism induced by collagen-epinephrine treatment