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FLASH GENE
Symbol SCUBE1 contributors: mct/npt - updated : 13-01-2021
HGNC name signal peptide, CUB domain, EGF-like 1
HGNC id 13441
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal signal peptide sequence
  • nine tandemly arranged epidermal growth factor (EGF)-like repeats
  • a spacer region
  • three cysteine-rich repeat motifs (CR) motifs with multiple potential N-linked glycosylation sites
  • one CUB domain at the C terminus
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • SCUBE family
    • CATEGORY adhesion , signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • may play important roles in development, inflammation, and thrombosis
  • platelet-derived protein that could function as a novel adhesive molecule and may play critical (patho)physiological roles in cardiovascular biology
  • platelet-endothelial secreted protein, elevated in patients with acute coronary syndrome and ischemic stroke
  • platelet-derived SCUBE1 plays a critical role in arterial thrombosis via its adhesive EGF-like repeats
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text
  • brain morphogenesis
    • PATHWAY
    metabolism
    signaling
    a component
  • SCUBE1 forms a complex with BMP2 ligand and its receptors, thus acting as a BMP co-receptor to augment BMP signal activity
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SCUBE1 directly binds to BMP7 and its receptors, functioning as a BMP co-receptor to promote BMP7 signaling
    • cell & other
    REGULATION
    Other plasma SCUBE1 might subject to a proteolytic regulation under pathological conditions
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    may be, in the del 22q13 syndrome
    constitutional     --over  
    in acute coronary syndrome (ACS) and acute ischemic stroke (AIS), but not in chronic coronary artery disease (CAD)
    constitutional     --over  
    elevated levels of SCUBE1, a novel platelet activation marker, in primary hypertensive patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • biomarker of platelet activation in acute coronary syndrome (ACS) and acute ischemic stroke (AIS)
  • is a novel platelet activation marker
  • increased serum SCUBE1 concentrations have close relation to increasing severity and poor prognosis of intracerebral hemorrhage (ICH)
  • plasma SCUBE1 measurement may have diagnostic, therapeutic, or prognostic value in testicular torsion (TT)
  • SCUBE1 may be a promising biomarker for the early diagnosis of ovarian torsion (OT)
    • Therapy target
    SystemTypeDisorderPubmed
    bloodcoagulation 
    blockade of soluble SCUBE1 might represent a novel antithrombotic strategy
    bloodcoagulation 
    targeting theadhesive motifs of SCUBE1 is a potential anti-thrombotic strategy
    ANIMAL & CELL MODELS
  • plasma deficiency of Sube1 diminished arterial thrombosis in mice and protected against lethal thromboembolism induced by collagen-epinephrine treatment