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FLASH GENE
Symbol UGT1A6 contributors: mct/npt - updated : 01-10-2014
HGNC name UDP glucuronosyltransferase 1 family, polypeptide A6
HGNC id 12538
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in undifferentiated cells (Siissalo 2008)
Susceptibility
  • resistance to aspirin
  • to bladder cancer
  • Variant & Polymorphism other
  • UGT1A6*2 may confer more rapid glucuronidation of salicylic acid (Feher 2009)
  • rs17863783 may protect from bladder cancer by increasing the removal of carcinogens from bladder epithelium by the UGT1A6.1 protein
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS