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FLASH GENE
Symbol UGT1A6 contributors: mct/npt - updated : 01-10-2014
HGNC name UDP glucuronosyltransferase 1 family, polypeptide A6
HGNC id 12538
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • UDP glucuronosyltransferase 1 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,nucleus
    basic FUNCTION
  • involved in the detoxication of phenolic compounds
  • glucuronosyltransferase activity
  • plays important roles in elimination of many xenobiotics, including drugs(
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with UGT1A1, UGT1A4, possibly by heterodimerization, and their effects on the enzymatic activities are complex depending on the isoforms and substrates (Fujiwara 2007)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in undifferentiated cells (Siissalo 2008)
    Susceptibility
  • resistance to aspirin
  • to bladder cancer
    • Variant & Polymorphism other
  • UGT1A6*2 may confer more rapid glucuronidation of salicylic acid (Feher 2009)
  • rs17863783 may protect from bladder cancer by increasing the removal of carcinogens from bladder epithelium by the UGT1A6.1 protein
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS