Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol UGT1A6 contributors: mct/npt - updated : 01-10-2014
HGNC name UDP glucuronosyltransferase 1 family, polypeptide A6
HGNC id 12538
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 liver    
 mouth   highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • UDP glucuronosyltransferase 1 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,nucleus
    basic FUNCTION
  • involved in the detoxication of phenolic compounds
  • glucuronosyltransferase activity
  • plays important roles in elimination of many xenobiotics, including drugs(
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with UGT1A1, UGT1A4, possibly by heterodimerization, and their effects on the enzymatic activities are complex depending on the isoforms and substrates (Fujiwara 2007)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in undifferentiated cells (Siissalo 2008)
    Susceptibility
  • resistance to aspirin
  • to bladder cancer
    • Variant & Polymorphism other
  • UGT1A6*2 may confer more rapid glucuronidation of salicylic acid (Feher 2009)
  • rs17863783 may protect from bladder cancer by increasing the removal of carcinogens from bladder epithelium by the UGT1A6.1 protein
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS