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FLASH GENE

Symbol

NR1I2

contributors: mct/npt - updated : 10-01-2016

HGNC name	nuclear receptor subfamily 1, group I, member 2
HGNC id	7968

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in adenocarcinoma tissue and columnar Barrett epithelium

Susceptibility

to ulcerative colitis (UC)

Variant & Polymorphism SNP	rs2276707 was weakly associated with UC susceptibility

Candidate gene
Marker	prognostic factor in epithelial ovarian cancer and may represent a useful marker to identify patients at risk of recurrence or death
Therapy target

ANIMAL & CELL MODELS

Pxr-deficient mice exhibit an exaggerated T lymphocyte proliferation and increased CD25 expression