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FLASH GENE
Symbol TNFRSF19 contributors: mct - updated : 26-08-2010
HGNC name tumor necrosis factor receptor superfamily, member 19
HGNC id 11915
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 29 aa signal peptide (3.3 kda)
  • three TNFR-Cys repeats
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Tnfrsf19 (71.1 pc)
    Homologene
    FAMILY
  • tumor necrosis factor receptor superfamily
    • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text single-pass type I membrane protein
    basic FUNCTION
  • involved in the induction of the caspase-independent apoptosis
  • can mediate activation of JNK and NF-kappa-B
  • acting as a tumor necrosis factor receptor
  • playing an essential role in embryonic development
  • may play some roles in the developing and adult olfactory system (Morikawa 2008)
  • mediating cellular responses to myelin inhibitors
  • essential role in hair follicle development (Pispa 2008)
  • novel function of TNFRSF19 as a factor mediating differentiation signals that determine the mesenchymal (stromal) stem cell differentiating fate into osteoblasts or adipocytes (Qiu 2010)
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
  • JNK cascade
  • EDAR and TNFSFR19 signalling pathways act redundantly to regulate initiation of hair follicle development(Pispa 2008)
    • a component forming a functional receptor complex with NgR and LINGO-1
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated with TRAF1, TRAF2, TRAF3 and TRAF5 (activation of JNK pathway)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker biomarker for melanoma
    Therapy target
  • also presents a potentially novel cell surface signaling target for inhibitors, cell and/or antibody-based immunotherapies (Spanjaard 2007)
    • ANIMAL & CELL MODELS