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FLASH GENE

Symbol

TNFRSF19

contributors: mct - updated : 26-08-2010

HGNC name	tumor necrosis factor receptor superfamily, member 19
HGNC id	11915

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	105.51 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
text structure	cis-regulatory elements found in promoters of human TNFRSF19 transcripts (Qiu 2010)

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018647 9 splicing 1485 NP_061117 - 423 - Kojima (2000), Qiu (2010) also called TRADEbeta 9 exons a 394 aa mature peptide (42.7 kda) TNFRSF19.1 NM_148957 10 splicing 4283 NP_683760 - 417 - Kojima (2000), Qiu (2010) also called TRADEalpha 10 exons having an unique 5' UTR and differing in the 3' end-region which includes a part of the coding sequence compared to variant 1 contains a major TRAF2-binding consensus sequence, (P/S/A/T)X(Q/E)E (SLQE at amino acid 413–416), which is absent in TNFRSF19.1. a 388 aa mature peptide (42 kda) TNFRSF19.2

EXPRESSION

Rna function	in embryo mRNA was exclusively expressed in the epithelium of many tissues, including neuroepithelium;in the developing central nervous system, strongly expressed in the ventricular and subventricular zones (Morikawa 2008)
Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       predominantly Skin/Tegument skin appendages hair follicle   highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular exocrine highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	brain, skin (epithelium)

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a 29 aa signal peptide (3.3 kda)
	three TNFR-Cys repeats

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to murine Tnfrsf19 (71.1 pc)

Homologene

FAMILY

tumor necrosis factor receptor superfamily

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
text	single-pass type I membrane protein

basic FUNCTION	involved in the induction of the caspase-independent apoptosis
	can mediate activation of JNK and NF-kappa-B
	acting as a tumor necrosis factor receptor
	playing an essential role in embryonic development
	may play some roles in the developing and adult olfactory system (Morikawa 2008)
	mediating cellular responses to myelin inhibitors
	essential role in hair follicle development (Pispa 2008)
	novel function of TNFRSF19 as a factor mediating differentiation signals that determine the mesenchymal (stromal) stem cell differentiating fate into osteoblasts or adipocytes (Qiu 2010)

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

signal transduction

	JNK cascade
	EDAR and TNFSFR19 signalling pathways act redundantly to regulate initiation of hair follicle development(Pispa 2008)

a component

forming a functional receptor complex with NgR and LINGO-1

INTERACTION

DNA

RNA

small molecule

protein

associated with TRAF1, TRAF2, TRAF3 and TRAF5 (activation of JNK pathway)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	biomarker for melanoma
Therapy target	also presents a potentially novel cell surface signaling target for inhibitors, cell and/or antibody-based immunotherapies (Spanjaard 2007)

ANIMAL & CELL MODELS