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FLASH GENE

Symbol

LRP1B

contributors: mct/npt - updated : 08-06-2021

HGNC name	low density lipoprotein-related protein 1B (deleted in tumors)
HGNC id	6693

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       loss of function in urothelial cancer, frequently inactivated in non small-cell lung carcinoma tumoral       loss of function results in changes to the tumor environment that confer cancer cells an increased growth and invasive capacity tumoral     --over   in Hepatocellular Carcinoma

Susceptibility

to obesity to idiopathic acquired pure red cell aplasia (PRCA)

Variant & Polymorphism SNP	single nucleotide polymorphism (rs431809) in intron 4, significantly correlated with both body mass index (BMI) and waist-hip-ratio (WHR)
	LRP1B mutations may be associated with acquired PRCA

Candidate gene
Marker	biomarker for thyroid cancer exhibiting differences in the correlation coefficients between benign and malignant samples that indicate its discriminatory power
	Nuclear LRP1B was significantly associated with poor patient prognosis in breast cancer cells and nuclear expression of LRP1B intracellular domain increased NEAT1 expression
Therapy target
	System Type Disorder Pubmed obesity     Genetic and epigenetic crosstalk of LRP1B gene may be implicated in the prevention and therapeutic approach to childhood obesity cancer digestive colon restoring the function of LRP1B would be a promising strategy for the treatment of colon cancer

ANIMAL & CELL MODELS