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FLASH GENE
Symbol LRP1B contributors: mct/npt - updated : 08-06-2021
HGNC name low density lipoprotein-related protein 1B (deleted in tumors)
HGNC id 6693
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Lrp1b
intraspecies homolog to LRP1
Homologene
FAMILY
  • low density lipoprotein receptor gene family ( LDLR)
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • putative endocytic receptor
  • transducer of extracellular signals, and may be involved in signal transduction (Shiroshima 2009)
  • suppressive roles of LRP1B in the progression of colon cancer
  • LRP1B plays a pivotal role in maintaining lipid homeostasis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding of PICK1 inhibits phosphorylation of LRP1B, but does not affect LRP1 phosphorylation (Shiroshima 2009)
  • HSF1 directly regulated the transcription of LRP1B and was involved in LRP1B-mediated lipid metabolism in hepatocellular carcinoma (HCC)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    in urothelial cancer, frequently inactivated in non small-cell lung carcinoma
    tumoral       loss of function
    results in changes to the tumor environment that confer cancer cells an increased growth and invasive capacity
    tumoral     --over  
    in Hepatocellular Carcinoma
    Susceptibility
  • to obesity
  • to idiopathic acquired pure red cell aplasia (PRCA)
    • Variant & Polymorphism SNP
  • single nucleotide polymorphism (rs431809) in intron 4, significantly correlated with both body mass index (BMI) and waist-hip-ratio (WHR)
  • LRP1B mutations may be associated with acquired PRCA
    • Candidate gene
    Marker
  • biomarker for thyroid cancer exhibiting differences in the correlation coefficients between benign and malignant samples that indicate its discriminatory power
  • Nuclear LRP1B was significantly associated with poor patient prognosis in breast cancer cells and nuclear expression of LRP1B intracellular domain increased NEAT1 expression
    • Therapy target
    SystemTypeDisorderPubmed
    obesity  
    Genetic and epigenetic crosstalk of LRP1B gene may be implicated in the prevention and therapeutic approach to childhood obesity
    cancerdigestivecolon
    restoring the function of LRP1B would be a promising strategy for the treatment of colon cancer
    ANIMAL & CELL MODELS