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FLASH GENE
Symbol GAL3ST1 contributors: mct - updated : 03-09-2010
HGNC name galactose-3-O-sulfotransferase 1
HGNC id 24240
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two potential N terminal glycosylation sites
    • HOMOLOGY
    interspecies homolog to murine Gal3st1 (84.7pc)
    Homologene
    FAMILY
  • galactose-3-O-sulfotransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text integral membrane protein
    basic FUNCTION
  • catalyzing the sulfation of membrane glycolipids
  • catalyzing the synthesis of galactosylceramide sulfate (the major component of myelin sheat) and monogalactosylalkylacylglycerol sulfate (present in spermatocytes)
  • aberrant usage of transcription initiation sites putatively involved in the cancer associated expression of CST
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    sphingolipid and glycerolipid biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by enhanced in renal cell carcinoma by EGF,TGF and HGF
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    enhanced activity in renal cell carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS