Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

GAL3ST1

contributors: mct - updated : 03-09-2010

HGNC name	galactose-3-O-sulfotransferase 1
HGNC id	24240

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis     moderately Urinary kidney tubule

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Membrane mucous membrane

cell lineage
cell lines	renal cancer cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two potential N terminal glycosylation sites

HOMOLOGY

interspecies

homolog to murine Gal3st1 (84.7pc)

Homologene

FAMILY

galactose-3-O-sulfotransferase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	integral membrane protein

basic FUNCTION	catalyzing the sulfation of membrane glycolipids
	catalyzing the synthesis of galactosylceramide sulfate (the major component of myelin sheat) and monogalactosylalkylacylglycerol sulfate (present in spermatocytes)
	aberrant usage of transcription initiation sites putatively involved in the cancer associated expression of CST

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

lipid/lipoprotein

signaling

sphingolipid and glycerolipid biosynthesis

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

activated by

enhanced in renal cell carcinoma by EGF,TGF and HGF

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function enhanced activity in renal cell carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS