Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SFTPA2 contributors: mct - updated : 15-10-2019
HGNC name surfactant, pulmonary-associated protein A2
HGNC id 10799
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text mid gestation fetal lung
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one c-type lectin family domain
  • one collagenous domain
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY collectin family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • important role in innate immunity
  • involved in host defense, also involved in the surface tension lowering ability of pulmonary surfactant
  • SFTPA1, SFTPA2 plays a key role in innate lung host defense, in surfactant-related functions, and in parturition
  • innate host defense molecules, surfactant protein A1 (SFTPA1), and SFTPA2 differentially affect the function and proteome of the alveolar macrophages
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • a complex with SFTPA1
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) IPF1
    Susceptibility
  • to respiratory distress in very premature infant
  • to tuberculosis
    • Variant & Polymorphism SNP , other
  • 6A2 overexpressed
  • 355C and 751C increasing the risk of tuberculosis in Ethiopia
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS