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Symbol SFTPA2 contributors: mct - updated : 15-10-2019
HGNC name surfactant, pulmonary-associated protein A2
HGNC id 10799
Corresponding disease
IPF1 pulmonary fibrosis, idiopathic 1
Location 10q22.3      Physical location : 81.315.608 - 81.320.163
Synonym name
  • 35 kDa pulmonary surfactant-associated protein
  • alveolar proteinosis protein
  • collectin 5
  • Synonym symbol(s) SP-A2, COLEC5, SP-2A beta, SP-A1, SP-A1 beta, SPAII, PSAP, PSP-A, PSPA, SFTP1B, FLJ79091, FLJ93678, MGC133169, MGC133366, MGC189714
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text clustered with SFTPA1
    STRUCTURE 4.61 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (TATA box)
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC387690 10 LOC387690 LOC387691 10 LOC387691 RAI17 10q23.2 retinoic acid induced 17 PPIF 10q22.3 peptidylprolyl isomerase F (cyclophilin F) FLJ90798 10q23.1 hypothetical protein FLJ90798 LOC338586 10q23.1 similar to XRnf12C LOC143244 10q23.1 similar to eukaryotic initiation factor 5A isoform I variant A LOC389981 10 similar to mannose-binding protein A LOC389982 10 similar to mKIAA1553 protein LOC387692 10 similar to KIAA2020 protein EIF5AP1 10q23.3 eukaryotic translation initiation factor 5A pseudogene 1 LOC389983 10 similar to Gene with similarity to rat kidney-specific (KS) gene SFTPA2 10q22-q23 surfactant, pulmonary-associated protein A2 SFTPA1 10q22.3 surfactant, pulmonary-associated protein A1 LOC389984 10 similar to KIAA1553 protein LOC389985 10 similar to bA182L21.1 (novel protein similar to hypothetical proteins) LOC389986 10 similar to bA182L21.1 (novel protein similar to hypothetical proteins) LOC340736 10q23.1 similar to Cathepsin L preproprotein LOC283004 10q23.1 similar to Geranylgeranyl transferase type I beta subunit (Type I protein geranyl-geranyltransferase beta subunit) (GGTase-I-beta) LOC387693 10 similar to BMS1-like, ribosome assembly protein; ribosome biogenesis protein BMS1 homolog; cDNA sequence BC030906; EST AA408648 SFTPD 10q22.3 surfactant, pulmonary-associated protein D LOC389987 10 similar to nuclear DNA-binding protein; small unique nuclear receptor corepressor; C1D DNA-binding protein LOC389988 10 similar to nuclear DNA-binding protein; small unique nuclear receptor corepressor; C1D DNA-binding protein LOC389989 10 hypothetical gene supported by BC016284; NM_173177 FLJ13263 10q23.1 hypothetical protein FLJ13263 PLAC9 10q23.2 placenta-specific 9 ANXA11 10q22.3 annexin A11 LOC143243 10q23.1 similar to eukaryotic initiation factor 5A isoform I variant A MAT1A 10q22 methionine adenosyltransferase I, alpha LOC143241 10q23.1 hypothetical protein BC019250 MGC16186 10q23.1 hypothetical protein MGC16186 MGC4248 10q23.1 hypothetical protein MGC4248 DC-TM4F2 10q23.1 tetraspanin similar to TM4SF9 LOC387694 10 similar to hypothetical protein D030001E08
    RNA
    TRANSCRIPTS type messenger
    text five different classes of transcripts alternatively spliced at their 5' end (McCormick)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2201 - 248 - 1992 1372511
    6 - 2204 - 248 - 1992 1372511
    5 - 2341 - 258 - 1992 1372511
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text mid gestation fetal lung
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one c-type lectin family domain
  • one collagenous domain
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY collectin family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • important role in innate immunity
  • involved in host defense, also involved in the surface tension lowering ability of pulmonary surfactant
  • SFTPA1, SFTPA2 plays a key role in innate lung host defense, in surfactant-related functions, and in parturition
  • innate host defense molecules, surfactant protein A1 (SFTPA1), and SFTPA2 differentially affect the function and proteome of the alveolar macrophages
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • a complex with SFTPA1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) IPF1
    Susceptibility
  • to respiratory distress in very premature infant
  • to tuberculosis
  • Variant & Polymorphism SNP , other
  • 6A2 overexpressed
  • 355C and 751C increasing the risk of tuberculosis in Ethiopia
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS