Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

FXYD3

contributors: mct/npt - updated : 15/11/2008

HGNC name	FXYD domain containing ion transport regulator 3
HGNC id	4027

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine       highly Endocrine pancreas         Nervous brain hindbrain cerebellum     Reproductive male system prostate     highly Respiratory lung         Urinary bladder       highly

cells

System Cell Pubmed Species Stage Rna symbol   granular cell

cell lineage
cell lines	breast tumor cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a 35 AA signature with the PFXYD motif at the beginning, spanning the membrane
	a cytoplasmic positively charged C terminus but lacking the phosphorylation sites of FXYD1
	a cleavable signal peptide

HOMOLOGY

Homologene

FAMILY

FXYD family

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	may be functioning as a chloride channel or as a chloride channel regulator
	may be involved in the proliferation, differentiation and axon elongation of granules cells as they mature and migrate to the internal granule layer
	may have been assembled from discrete structural modules through exon shuffling

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS