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FLASH GENE

Symbol

FXYD3

contributors: mct/npt - updated : 15/11/2008

HGNC name	FXYD domain containing ion transport regulator 3
HGNC id	4027

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	8.43 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	three transcripts : 0,5kb, 2,5kb, 3kb

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 or FXYD3s 9 - 1304 - 87 in differentiated cells Arimochi, Bibert (2006) 72p100 sequence identity with mouse FXYD3 decreases the apparent K(+) and Na(+) affinity of Na,K-ATPase over a large range of membrane potentials variant 2 or FXYD3l 9 - 1466 - 113 mainly expressed in nondifferentiated cells Arimochi, Bibert (2006) has a 26-amino acid insertion after the transmembrane domain decreases the apparent K(+) affinity only at slightly negative and positive membrane potentials and increases the apparent Na(+) affinity of Na,K-ATPase variant 3 - - 1588 15 144 - Franzin (2007) variant 4 - - 778 - 96 - Franzin (2007) variant 5 - - 843 - 61 - Franzin (2007) variant 6 - - 759 - 61 - Franzin (2007) variant 7 - - 1466 - 87 - Franzin (2007) variant 8 - - 1460 - 113 - Franzin (2007)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine       highly Endocrine pancreas         Nervous brain hindbrain cerebellum     Reproductive male system prostate     highly Respiratory lung         Urinary bladder       highly

cells

System Cell Pubmed Species Stage Rna symbol   granular cell

cell lineage
cell lines	breast tumor cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a 35 AA signature with the PFXYD motif at the beginning, spanning the membrane
	a cytoplasmic positively charged C terminus but lacking the phosphorylation sites of FXYD1
	a cleavable signal peptide

HOMOLOGY

Homologene

FAMILY

FXYD family

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	may be functioning as a chloride channel or as a chloride channel regulator
	may be involved in the proliferation, differentiation and axon elongation of granules cells as they mature and migrate to the internal granule layer
	may have been assembled from discrete structural modules through exon shuffling

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS