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FLASH GENE
Symbol OGT contributors: mct/pgu - updated : 21-11-2016
HGNC name O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
HGNC id 8127
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --other  
homeostasis of OGT cycling is critical to, and its dysregulation is involved in, neurodegenerative diseases
constitutional     --over  
implicated in major diseases, such as diabetes and its complications and cardiovascular and neurodegenerative diseases
constitutional     --over  
results in an increase in abnormal chromosomal bridge formation
constitutional     --over  
increased the inhibitory phosphorylation of cyclin-dependent kinase 1 (CDK1) and reduced the phosphorylation of CDK1 target proteins
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
neurologyneurodegenerativealzheimer
cycling provides a new target for investigation of these disease mechanisms and for drug development
ANIMAL & CELL MODELS