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FLASH GENE
Symbol OGT contributors: mct/pgu - updated : 21-11-2016
HGNC name O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
HGNC id 8127
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal region consisting of a series of tetratricopeptide repeat (TPR) units19, 20 and a multidomain catalytic region
  • thirteen tetratricopeptide (TPR) repeats (twelve full domain and one truncated) interacting with the coiled-coil domains of ALS2CR3 and OIP106
  • a possible phosphatidylinositol (3,4,5)-trisphosphate (PIP3) binding domain involved in membrane recruitment in response to insulin signalling
    • conjugated PhosphoP , Other
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to rattus Ogt (99.4 pc)
    homolog to murine Ogt (99.6 pc)
    Homologene
    FAMILY
  • O-GlcNAc transferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text expressed in the nucleocytoplasmic compartments
    basic FUNCTION
  • involved in addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine
  • OGT modification participates in the regulation of CAMK4 activation and function, possibly coordinating nutritional signals with the immune and nervous systems (
  • essential (in mouse) for embryonic stem cell viability
  • regulates mitotic chromatin dynamics
  • catalyzes O-GlcNAc) addition to numerous cellular proteins including transcription and nuclear pore complexes and plays a key role in cellular signaling
  • catalyses the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine (UDP-GlcNAc) to serines and threonines of cytoplasmic, nuclear and mitochondrial proteins
  • function of OGT in hormone signaling
  • modification of OGT is involved in many important cellular processes
  • essential role of O-GlcNAcylation during early development
  • TET2-dependent O-GlcNAcylation of chromatinand the double epigenetic modifications on both DNA and histones by TET2 and OGT coordinate together for the regulation of gene transcription
  • catalyzes serine and threonine glycosylation
    • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling signal transduction
    protein glycosylation
    a component
  • heterotrimer composed of two 110 kDa and one 78kDa (proteolytic product of the former) subunits
  • large proportion of the signaling enzyme OGT is complexed with HCFC1 and this interaction is essential for HCFC1 cleavage
  • BAP1 forms a core complex with HCFC1 and OGT that can differentially recruit additional histone-modifying enzymes to regulate gene expression and thereby preserve normal hematopoiesis
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with THAP1, THAP3 and thus involved in cell proliferation
  • HCFC1 is required for stabilizing OGT in the nucleus (interactions of OGT with multiple HCFC1 domains may indicate that OGT has several functions in association with HCFC1)
  • TAB1 is modified through OGT on a single site, Ser395 (this modification is induced by IL1 and osmotic stress, known inducers of the MAP3K7 signalling cascade)
  • associates with ligand-bound glucocorticoid receptor in a multi-protein repression complex
  • interacts with the tetratricopeptide repeat binding site of HSP90AA1
  • TET2 and TET3 associate with OGT, an enzyme that by itself catalyses the addition of O-GlcNAc onto serine and threonine residues (O-GlcNAcylation)
  • OGT associates with TET2 at transcription start sites
  • TET1 and TET2 as stable partners of OGT in the nucleus of ESCs
  • link between TET1 and OGT activities in regulating CpG island methylation
  • POU2F1 integrates metabolic and stress signals via OGT modification to regulate target gene activity
  • OGT-modification of CAMK2A is a novel signalling event in pathways that may contribute critically to cardiac and neuronal pathophysiology in diabetes and other diseases
  • OGT is not only a major TET3-interacting protein but also regulates TET3 subcellular localization and enzymatic activity
  • mediates O-GlcNAcylation of the SNARE protein SNAP29 and regulates autophagy in a nutrient-dependent manner
  • OGT modifies and regulates an essential epigenetic tool, RNF2, which may contribute to embryonic stem cells (hESC) pluripotency maintenance and differentiation
  • distinct OGT-binding sites in HCFC1 promote proteolysis
  • KMT2E protein stability is cooperatively regulated by O-GlcNAc transferase (OGT) and ubiquitin-specific protease 7 (USP7)
    • cell & other
    REGULATION
    Other acetylated
    HSP90AA1 is involved in the regulation of OGT and O-GlcNAc modification
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    homeostasis of OGT cycling is critical to, and its dysregulation is involved in, neurodegenerative diseases
    constitutional     --over  
    implicated in major diseases, such as diabetes and its complications and cardiovascular and neurodegenerative diseases
    constitutional     --over  
    results in an increase in abnormal chromosomal bridge formation
    constitutional     --over  
    increased the inhibitory phosphorylation of cyclin-dependent kinase 1 (CDK1) and reduced the phosphorylation of CDK1 target proteins
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerativealzheimer
    cycling provides a new target for investigation of these disease mechanisms and for drug development
    ANIMAL & CELL MODELS