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FLASH GENE

Symbol

KLF13

contributors: mct/ - updated : 09-03-2018

HGNC name	Kruppel-like factor 13
HGNC id	13672

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	51.02 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
text structure	promoter was trans-activated by co-expressed GATA-1 through the sequence containing two CCAAT motifs, suggesting that GATA-1 is involved in the abundant expression of KLF13 mRNA in the erythroid tissue

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_015995 2 - 6817 NP_057079 - 288 - 2005 15716005 NM_001302461 1 - 1241 NP_001289390 - 280 - 2005 15716005

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus         Cardiovascular heart       predominantly Digestive liver       highly Reproductive male system testis     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone       Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic erythroid Blood/Hematopoietic leukocyte Lymphoid/Immune lymphocyte

cell lineage	erythroid cell lines, highly
cell lines
fluid/secretion

at STAGE

physiological period

fetal

Text

liver

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	putative transactivation domain rich in proline and alanine at the N terminus (3PXXP motifs) associating with SH3 domain of tyrosine kinases
	a highly conserved 81 AA DNA binding domain
	a repression domain
	a nuclear localization signal (NLS)
	three Sp1-like zinc finger motifs at the C terminus

HOMOLOGY

Homologene

FAMILY

Sp1 C2H2-type zinc-finger protein family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	activation of globin genes, predominantly gamma and a wide range of genes in cells of erythroid lineage
	important component of the transcription network required for heart development
	is involved in the normal control of erythropoiesis
	involved in the development of B and T cells at multiple stages
	involved at multiple different checkpoints in development that require signalling through the TCR, pre-BCR or mature BCR
	key role for KLF13 in the expression of IL-4 in CD4(+) T cells

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	repressing CYP1A1 gene promoter via the BTE site
	KLF13 binds proximal LDLR DNA sequences and exogenous oxysterol up-regulates such binding
	binding the CTCB box and activating RANTES (CCL5)
	interaction with GATA4, a dosage-sensitive cardiac regulator (may be GATA4 modifier)
	controls the late (3-5 days after activation) expression of CCL5 in T lymphocytes and that KLF13 itself is translationally regulated through the 5prime -untranslated region of its mRNA
	key role for KLF13 in the expression of IL4 in CD4(+) T cells
	KLF13 cooperates with MAF to regulate IL4 expression in CD4+ T cells
	ACOT7 is transcriptionally activated by KLF13 and promotes the progression of hepatocellular carcinoma

cell & other

REGULATION

Other

activated after T cell activation with other genes and allowing T cells to rapidly adjust CCL5 expression in response to changes in cellular environment stress or growth factors

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       may be causative for congenital heart disease tumoral     --over   in Hepatocellular carcinoma (HCC) tissues and facilitated HCC progression

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	viable Klf13(-/-) mice had reduced numbers of circulating erythrocytes and a larger spleen
	in murine T lymphocytes, Klf13 protein is abundant because of the absence of Fbxw7