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FLASH GENE
Symbol KLF11 contributors: mct - updated : 25-01-2014
HGNC name Kruppel-like factor 11
HGNC id 11811
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   highly Homo sapiens
Endocrinepancreas   moderately Homo sapiens
 thyroid   highly
Reproductivefemale systemovary  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadiposebrown   Homo sapiens
Connectiveadiposewhite   Homo sapiens
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell Homo sapiens
Endocrineislet cell (alpha,beta...) Homo sapiens
not specificadipocyte Homo sapiens
cell lineage erythroid cells
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two acidic and proline-rich N terminal regions
  • a highly conserved 81 AA DNA binding domain
  • three Sp1-like zinc finger motifs at the C terminus
  • HOMOLOGY
    intraspecies paralog to TIEG1
    Homologene
    FAMILY
  • TGF beta inducible Sp1-like protein family
  • SP/KLF factors of zinc finger DNA-binding regulatory proteins
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • stress increases KLF11 expression and induces its nuclear translocation and contributes to increase in MAOA expression
  • basic FUNCTION
  • regulation of cell growth and transcriptional repressor
  • pancreas-enriched transcription factor acting as negative regulator of exocrine cell growth and glucose-inducible regulator of the insulin gene
  • playing a role in the regulation of pancreatic beta cell physiology, and its variants may contribute to the development of diabetes
  • not absolutely required for hematopoiesis, growth, and development
  • playing a central role in TGFbeta-induced c-myc repression and antiproliferation
  • mediates a novel mechanism in transforming growth factor beta-induced growth inhibition that is inactivated in pancreatic cancer
  • involved in activation of the proinsulin promoter
  • TGF-beta-inducible zinc finger protein, inducing apoptosis and inhibiting cell growth
  • serves as a downstream mediator of TGF-beta, bridging TGF-beta-dependent signaling to the intracellular pathway of apoptosis
  • regulates PDX1 transcription in beta cells through two evolutionarily conserved GC-rich motifs
  • role of KLF11 as a key mediator of prostaglandin biosynthesis
  • KLF11 and KLF15 enhanced UCP1 expression level during brown adipocyte differentiation through their direct interaction with specific binding domains of the UCP1 promoter
  • participates in the dexamethasone-induced transcriptional activation of MAOA
  • functional role for KLF11 in mesenchymal cells and in mesenchymal cell dysfunction
  • participates in diabetes and regulates hepatic lipid metabolism
  • having an anti-hypertrophic and anti-fibrotic role for the heart
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • glucocorticoid-KLF11-MAOA pathway may play a crucial role in modulating distinct pathophysiological steps in stress-related disorders
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activation of epsilon and gamma globin and weakly beta globin genes
  • interacting with INS (KLF11 overexpression-mediated inhibition of proinsulin gene expression and characterise a prominent role for the CACCC box in maintaining basal proinsulin promoter activity)
  • association with EP300, a coactivator shared among most MODY proteins, supports a critical role for this histone acetyltransferase protein in pancreatic beta cell development and function
  • interacting with PLA2G4A (binding to distinct sites the PLA2G4A promoter and recruiting chromatin silencer complexes)
  • bound to a GC-box of the UCP1 promoter and the binding was essential for UCP1 expression during brown adipocyte differentiation
  • recruits CBX5 and its histone methyltransferase, SUV39H1, to promoters to limit KLF11-mediated gene activation
  • KLF11 regulates the expression of CXCR4 at a specific KLF11 binding site
  • is an MAOA regulator and is produced in response to neuronal stress, which transcriptionally activates MAOA
  • potently inhibits NFKB signaling pathway via physical interaction with RELA
  • direct transcriptional target of PPARG, which plays a critical role in the cerebrovascular protection after ischaemic insults
  • interacts directly with COL1A2 promoter in mesenchymal cells to repress its activity
  • cell & other
    REGULATION
    activated by upregulated by TGFB1 and serum deprivation
    ASSOCIATED DISORDERS
    corresponding disease(s) MODY7
    Susceptibility to non insulin dependent diabetes
    Variant & Polymorphism SNP Gln62Arg associated with non insulin dependent diabetes
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabete  
    target for therapy of diabetes
    cardiovascularaquiredheart failure
    KLF11 activator may serve as candidate drug for heart failure patients
    ANIMAL & CELL MODELS