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FLASH GENE

Symbol

KLF11

contributors: mct - updated : 25-01-2014

HGNC name	Kruppel-like factor 11
HGNC id	11811

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003597 4 - 4051 NP_003588 55 512 - 2011 15774581 NM_001177716 4 - 3906 NP_001171187 - 495 - 2011 15774581 NM_001177718 4 - 4054 NP_001171189 - 495 - 2011 15774581

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       highly Homo sapiens Endocrine pancreas       moderately Homo sapiens   thyroid       highly Reproductive female system ovary     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose brown     Homo sapiens Connective adipose white     Homo sapiens Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell Homo sapiens Endocrine islet cell (alpha,beta...) Homo sapiens not specific adipocyte Homo sapiens

cell lineage	erythroid cells
cell lines
fluid/secretion

at STAGE

physiological period

fetal

Text

liver

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two acidic and proline-rich N terminal regions
	a highly conserved 81 AA DNA binding domain
	three Sp1-like zinc finger motifs at the C terminus

HOMOLOGY

intraspecies

paralog to TIEG1

Homologene

FAMILY	TGF beta inducible Sp1-like protein family
	SP/KLF factors of zinc finger DNA-binding regulatory proteins

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	stress increases KLF11 expression and induces its nuclear translocation and contributes to increase in MAOA expression

basic FUNCTION	regulation of cell growth and transcriptional repressor
	pancreas-enriched transcription factor acting as negative regulator of exocrine cell growth and glucose-inducible regulator of the insulin gene
	playing a role in the regulation of pancreatic beta cell physiology, and its variants may contribute to the development of diabetes
	not absolutely required for hematopoiesis, growth, and development
	playing a central role in TGFbeta-induced c-myc repression and antiproliferation
	mediates a novel mechanism in transforming growth factor beta-induced growth inhibition that is inactivated in pancreatic cancer
	involved in activation of the proinsulin promoter
	TGF-beta-inducible zinc finger protein, inducing apoptosis and inhibiting cell growth
	serves as a downstream mediator of TGF-beta, bridging TGF-beta-dependent signaling to the intracellular pathway of apoptosis
	regulates PDX1 transcription in beta cells through two evolutionarily conserved GC-rich motifs
	role of KLF11 as a key mediator of prostaglandin biosynthesis
	KLF11 and KLF15 enhanced UCP1 expression level during brown adipocyte differentiation through their direct interaction with specific binding domains of the UCP1 promoter
	participates in the dexamethasone-induced transcriptional activation of MAOA
	functional role for KLF11 in mesenchymal cells and in mesenchymal cell dysfunction
	participates in diabetes and regulates hepatic lipid metabolism
	having an anti-hypertrophic and anti-fibrotic role for the heart

CELLULAR PROCESS	cell life, proliferation/growth
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

glucocorticoid-KLF11-MAOA pathway may play a crucial role in modulating distinct pathophysiological steps in stress-related disorders

a component

INTERACTION

DNA

RNA

small molecule

protein	activation of epsilon and gamma globin and weakly beta globin genes
	interacting with INS (KLF11 overexpression-mediated inhibition of proinsulin gene expression and characterise a prominent role for the CACCC box in maintaining basal proinsulin promoter activity)
	association with EP300, a coactivator shared among most MODY proteins, supports a critical role for this histone acetyltransferase protein in pancreatic beta cell development and function
	interacting with PLA2G4A (binding to distinct sites the PLA2G4A promoter and recruiting chromatin silencer complexes)
	bound to a GC-box of the UCP1 promoter and the binding was essential for UCP1 expression during brown adipocyte differentiation
	recruits CBX5 and its histone methyltransferase, SUV39H1, to promoters to limit KLF11-mediated gene activation
	KLF11 regulates the expression of CXCR4 at a specific KLF11 binding site
	is an MAOA regulator and is produced in response to neuronal stress, which transcriptionally activates MAOA
	potently inhibits NFKB signaling pathway via physical interaction with RELA
	direct transcriptional target of PPARG, which plays a critical role in the cerebrovascular protection after ischaemic insults
	interacts directly with COL1A2 promoter in mesenchymal cells to repress its activity

cell & other

REGULATION

activated by

upregulated by TGFB1 and serum deprivation

ASSOCIATED DISORDERS

corresponding disease(s)

MODY7

Susceptibility

to non insulin dependent diabetes

Variant & Polymorphism SNP	Gln62Arg associated with non insulin dependent diabetes

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed diabete     target for therapy of diabetes cardiovascular aquired heart failure KLF11 activator may serve as candidate drug for heart failure patients

ANIMAL & CELL MODELS