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FLASH GENE
Symbol TH1L contributors: - updated : 12-09-2006
HGNC name TH1-like (Drosophila)
HGNC id 15934
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a phorbol-ester/DAG-type zinc finger
  • a protein kinase domain
  • a RBD(ras-binding) domain
    • HOMOLOGY
    interspecies homolog to Drosophila melanogaster th1l
    homolog to murine Th1l
    Homologene
    FAMILY NELF complex
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • negatively regulating the elongation of transcription
    • by RNA polymerase II
  • involved in the transduction of mitogenic signals from the cell membrane to the nucleus
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • 4 subunits: WHSC2/NELF-A, COBRA1/NELF-B, TH1L (isoform
    • NELF-C or isoform NELF-D) and RDBP/NELF-E
  • part of the NELF complex
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
    binds 2 zinc ions per subunit
    protein
  • interacts with ARAF1
  • interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS