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FLASH GENE
Symbol TH1L contributors: - updated : 12-09-2006
HGNC name TH1-like (Drosophila)
HGNC id 15934
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinesmall intestine  highly
 salivary gland   highly
Endocrineadrenal gland    
 thyroid    
Reproductivefemale systemuteruscervix highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text fetal tissues
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a phorbol-ester/DAG-type zinc finger
  • a protein kinase domain
  • a RBD(ras-binding) domain
    • HOMOLOGY
    interspecies homolog to Drosophila melanogaster th1l
    homolog to murine Th1l
    Homologene
    FAMILY NELF complex
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • negatively regulating the elongation of transcription
    • by RNA polymerase II
  • involved in the transduction of mitogenic signals from the cell membrane to the nucleus
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • 4 subunits: WHSC2/NELF-A, COBRA1/NELF-B, TH1L (isoform
    • NELF-C or isoform NELF-D) and RDBP/NELF-E
  • part of the NELF complex
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
    binds 2 zinc ions per subunit
    protein
  • interacts with ARAF1
  • interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS