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FLASH GENE

Symbol

TH1L

contributors: - updated : 12-09-2006

HGNC name	TH1-like (Drosophila)
HGNC id	15934

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed - - - 2400 65.5 581 - Bonthron variant 1 - - - 66.2 590 - Moore variant 2 - - - - >380 - Moore fragment variant 4 - - - 22.9 201 - Moore - - - - - >389 - Bonthron fragment - - - - - >414 - Bonthron fragment

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive intestine small intestine     highly   salivary gland       highly Endocrine adrenal gland           thyroid         Reproductive female system uterus cervix   highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Muscular striatum cardiac     Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	fetal tissues

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a phorbol-ester/DAG-type zinc finger
	a protein kinase domain
	a RBD(ras-binding) domain

HOMOLOGY

interspecies	homolog to Drosophila melanogaster th1l
	homolog to murine Th1l

Homologene

FAMILY

NELF complex

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	negatively regulating the elongation of transcription
	by RNA polymerase II
	involved in the transduction of mitogenic signals from the cell membrane to the nucleus

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	4 subunits: WHSC2/NELF-A, COBRA1/NELF-B, TH1L (isoform
	NELF-C or isoform NELF-D) and RDBP/NELF-E
	part of the NELF complex

INTERACTION

DNA

RNA

small molecule	metal binding,
	binds 2 zinc ions per subunit

protein	interacts with ARAF1
	interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS