Selected-GenAtlas references SOURCE GeneCards NCBI Gene Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TH1L contributors: - updated : 12-09-2006
HGNC name TH1-like (Drosophila)
HGNC id 15934
Location 20q13      Physical location : 57.556.310 - 57.570.186
Synonym symbol(s) HSPC130,TH1, NELF-C, NELF-D
DNA
TYPE functioning gene
SPECIAL FEATURE opposite orientation, tail to tail
text
  • tail to tail to CTSZ,transcribed in the opposite direction from GNAS1
    • STRUCTURE 13.00 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure
  • within the first exon
    • MAPPING cloned Y linked N status provisional
    Map see GNAS
    regionally located downstream of GNAS1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - 2400 65.5 581 - Bonthron
    - - - 66.2 590 - Moore
    - - - - >380 - Moore
    fragment
    - - - 22.9 201 - Moore
    - - - - - >389 - Bonthron
    fragment
    - - - - - >414 - Bonthron
    fragment
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinesmall intestine  highly
     salivary gland   highly
    Endocrineadrenal gland    
     thyroid    
    Reproductivefemale systemuteruscervix highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text fetal tissues
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a phorbol-ester/DAG-type zinc finger
  • a protein kinase domain
  • a RBD(ras-binding) domain
    • HOMOLOGY
    interspecies homolog to Drosophila melanogaster th1l
    homolog to murine Th1l
    Homologene
    FAMILY NELF complex
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • negatively regulating the elongation of transcription
    • by RNA polymerase II
  • involved in the transduction of mitogenic signals from the cell membrane to the nucleus
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • 4 subunits: WHSC2/NELF-A, COBRA1/NELF-B, TH1L (isoform
    • NELF-C or isoform NELF-D) and RDBP/NELF-E
  • part of the NELF complex
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
    binds 2 zinc ions per subunit
    protein
  • interacts with ARAF1
  • interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS