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FLASH GENE
Symbol TH1L contributors: - updated : 12-09-2006
HGNC name TH1-like (Drosophila)
HGNC id 15934
Location 20q13      Physical location : 57.556.310 - 57.570.186
Synonym symbol(s) HSPC130,TH1, NELF-C, NELF-D
DNA
TYPE functioning gene
SPECIAL FEATURE opposite orientation, tail to tail
text
  • tail to tail to CTSZ,transcribed in the opposite direction from GNAS1
  • STRUCTURE 13.00 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure
  • within the first exon
  • MAPPING cloned Y linked N status provisional
    Map see GNAS
    Physical map
    LOC284754 20q13.31 hypothetical gene supported by BC037891 SPO11 20q13.2-q13.3 SPO11 meiotic protein covalently bound to DSB-like (S. cerevisiae) RAE1 20q13.31 RAE1 RNA export 1 homolog (S. pombe) RNPC1 20q13.31 RNA-binding region (RNP1, RRM) containing 1 LOC149767 20q13.31 similar to dJ579F20.1 (high-mobility group (nonhistone chromosomal) protein 1-like 1) CTCFL 20q13.31 CCCTC-binding factor (zinc finger protein)-like PCK1 20q13.3 phosphoenolpyruvate carboxykinase 1 (soluble) ZBP1 17q21.3 Z-DNA binding protein 1 TMEPAI 20q13.31-q13.33 transmembrane, prostate androgen induced RNA C20orf85 20q13.32 chromosome 20 open reading frame 85 C20orf86 20q13.32 chromosome 20 open reading frame 86 PPP4R1L 20q13.32 protein phosphatase 4, regulatory subunit 1-like RAB22A 20q13 RAB22A, member RAS oncogene family VAPB 20q13 VAMP (vesicle-associated membrane protein)-associated protein B and C FLJ90166 20q13.32 hypothetical protein FLJ90166 MGC4294 20q13.32 hypothetical protein MGC4294 LOC388801 20 LOC388801 STX16 20q13.32 syntaxin 16 NPEPL1 20q13.32 aminopeptidase-like 1 LOC388802 20 hypothetical gene supported by AK124059 LOC391258 20 similar to Hypothetical protein KIAA0233 GNAS 20q13.2-q13.3 GNAS complex locus TH1L 20q13 TH1-like (Drosophila) CTSZ 20q13 cathepsin Z TUBB1 20q13.32 tubulin, beta 1 ATP5E 20q13.2-q13.3 ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit C20orf45 20q13.32 chromosome 20 open reading frame 45 MRPS16P 20q13.32 chromosome 20 open reading frame 45 LOC343629 20q13.32 similar to bA379F14.2 (novel protein) C20orf174 20q13.32 chromosome 20 open reading frame 174 EDN3 20q13.2-q13.3 endothelin 3 LOC391259 20 similar to bA164D18.1 (novel protein similar to KIAA0233) SCAPIN1 20q13.32-q13.33 scapinin SYCP2 20q13.33 synaptonemal complex protein 2 PPP1R3D 20q13.3 protein phosphatase 1, regulatory subunit 3D C20orf177 20q13.2-q13.33 chromosome 20 open reading frame 177 CDH26 20q13.2-q13.33 cadherin-like 26 FLJ33860 20q13.33 hypothetical protein FLJ33860 LOC388803 20 LOC388803 LOC388804 20 LOC388804 MTCO2L 20 cytochrome c oxidase II-like
    regionally located downstream of GNAS1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - 2400 65.5 581 - Bonthron
    - - - 66.2 590 - Moore
    - - - - >380 - Moore
    fragment
    - - - 22.9 201 - Moore
    - - - - - >389 - Bonthron
    fragment
    - - - - - >414 - Bonthron
    fragment
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinesmall intestine  highly
     salivary gland   highly
    Endocrineadrenal gland    
     thyroid    
    Reproductivefemale systemuteruscervix highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text fetal tissues
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a phorbol-ester/DAG-type zinc finger
  • a protein kinase domain
  • a RBD(ras-binding) domain
  • HOMOLOGY
    interspecies homolog to Drosophila melanogaster th1l
    homolog to murine Th1l
    Homologene
    FAMILY NELF complex
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • negatively regulating the elongation of transcription
  • by RNA polymerase II
  • involved in the transduction of mitogenic signals from the cell membrane to the nucleus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • 4 subunits: WHSC2/NELF-A, COBRA1/NELF-B, TH1L (isoform
  • NELF-C or isoform NELF-D) and RDBP/NELF-E
  • part of the NELF complex
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
    binds 2 zinc ions per subunit
    protein
  • interacts with ARAF1
  • interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS