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FLASH GENE
Symbol MYO3A contributors: mct - updated : 29-08-2015
HGNC name myosin IIIA
HGNC id 7601
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a unique N-terminal kinase domain
  • three consensus calmodulin-binding motifs
  • catalytic domain
  • a C-terminal actin-binding domain
    • HOMOLOGY
    interspecies homolog to Drosophila Ninac
    Homologene
    FAMILY myosin family
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microfilament
    basic FUNCTION
  • actin-based motor protein having a protein kinase activity
  • can spend a majority of its ATP hydrolysis cycling time on actin
  • MYO3A and ESPN have been shown to influence the length of mechanosensory stereocilia 8)
  • transports cargo to the distal end of actin protrusions and contains a kinase domain that is thought to autoregulate its activity
  • like MYO3A, MYO3B can elongate filopodia by transporting ESPN to the polymerizing end of actin filaments
  • targets actin protrusion tips using a motility mechanism dependent on both motor and tail actin-binding activity
  • phosphorylation-dephosphorylation mechanism plays an essential role in mediating the transport and actin bundle formation and stability functions of MYO3A
    • CELLULAR PROCESS nucleotide, genomic integrity
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling sensory transduction/hearing
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ESPN colocalizes with MYO3A at stereocilia tips and interacts with a unique conserved domain of MYO3A 8)
  • interaction of MYO3A with the cytosolic tail of the integral tip-link protein protocadherin 15 (PCDH15), a core component of MET complex
    • cell & other
    REGULATION
    Other its activity is regulated by phosphorylation of the kinase domain activation loop
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNB30
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • outer hair cells of Myo3a(KI/KI) mice degenerate with age in a pattern consistent with their progressive hearing loss