| Symbol
| CHGA
| contributors: mct/npt/pgu - updated : 08-06-2013
|
| HGNC name
| chromogranin A (parathyroid secretory protein 1)
|
| HGNC id
| 1929
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| constitutional
|
|
| --over
|
| |
in inflammatory bowel disease | | tumoral
|
|
| --over
|
| |
in pancreatic tumors | | constitutional
|
|
| --over
|
|
in cardiomyocytes could limit the hypoxia/reoxygenation injuries at molecular levels  | | tumoral
|
|
| --over
|
| |
associated with increased noradrenergic activity and tumour size in patients with a single head and neck paragangliomas | |
| Susceptibility
|
to changes in blood pressure to hypertensive end-stage renal disease (ESRD) |
| Variant & Polymorphism
other
| common genetic variants in the CHGA promoter may regulate heritable changes in blood pressure |
|
common variants associate with the risk of hypertensive ESRD in blacks |
| 
|
| Candidate gene
| for autonomic dysfunction syndromes and hypertension |
Marker
Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| cardiovascular | atheroma | cardiac | |
| potential therapeutic target for patients with myocardial ischemia |
| | |