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FLASH GENE
Symbol TM6SF2 contributors: mct - updated : 22-11-2016
HGNC name transmembrane 6 superfamily member 2
HGNC id 11861
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six transmembrane domains
    • HOMOLOGY
    interspecies homolog to chimpanzee TM6SF2 (99.7 pc)
    homolog to murine Tm6sf2 (79 pc)
    intraspecies paralog to TM6SF1
    Homologene
    FAMILY
  • transmembrane 6 superfamily
  • TM6SF family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to non-alcoholic fatty liver disease (NAFLD)
    Variant & Polymorphism SNP
  • TM6SF2 p.E167K variants represent genetic risk factors for non-alcoholic fatty liver disease (NAFLD)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS