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FLASH GENE
Symbol TM6SF2 contributors: mct - updated : 22-11-2016
HGNC name transmembrane 6 superfamily member 2
HGNC id 11861
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  predominantly
 intestinelarge intestinecolon lowly
 liver   lowly
Reproductivefemale systemovary  lowly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six transmembrane domains
    • HOMOLOGY
    interspecies homolog to chimpanzee TM6SF2 (99.7 pc)
    homolog to murine Tm6sf2 (79 pc)
    intraspecies paralog to TM6SF1
    Homologene
    FAMILY
  • transmembrane 6 superfamily
  • TM6SF family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to non-alcoholic fatty liver disease (NAFLD)
    Variant & Polymorphism SNP
  • TM6SF2 p.E167K variants represent genetic risk factors for non-alcoholic fatty liver disease (NAFLD)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS