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FLASH GENE
Symbol SIN3B contributors: mct/pgu - updated : 01-02-2018
HGNC name SIN3 homolog B, transcriptional regulator (yeast)
HGNC id 19354
PROTEIN
PHYSICAL PROPERTIES acid Amphiphilic
STRUCTURE
motifs/domains
  • four PAH (paired amphipathic helix) motifs
  • a poly-proline, a poly-alanine-glutamine and acidic regions
    • HOMOLOGY
    interspecies homolog to murine Sin3b (92.7pc)
    intraspecies paralog to SIN3A
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • acting as a transcriptional repressor
  • is required for cellular senescence
  • transcriptional role for SIN3A and SIN3B proteins associated with maintenance of differentiated muscle cells
  • SIN3A and SIN3B regulate gene expression at the chromatin-level by serving as an anchor onto which the core SIN3/HDAC complex is assembled
  • essential role of SIN3B as an important associate of TP53 in mediating the cellular responses to stress and in the transcriptional repression of genes encoding for heat shock proteins or proteins involved in regulation of cell cycle and apoptosis
  • SIN3B cooperated with G9a, a histone H3K9 methyltransferase, to induce a repressive chromatin structure surrounding the collagen gene transcription start site in response to IFNG1 stimulation
  • expression of the chromatin-associated SIN3B protein is stimulated by oncogenic stress, and is required for oncogene-induced senescence
  • stress-induced SIN3B activation is TP53-dependent and is essential for TP53-mediated repression of its selective target genes
  • metastasis suppressive roles of SIN3A and metastasis promoting roles of SIN3B in breast cancer
  • SIN3B is a novel and critical regulator of Hematopoietic stem cells (HSCs) functions
  • crucial role of SIN3B for central nervous system development, anterior cartilage patterning, and growth
  • SIN3A and SIN3B contribute likely to repressor function of enhancers and promoters in peripheral blood mononuclear cells (PBMCs)
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming a complex with FOXK1 which represses transcription
  • potential member of a corepressor complex involving selective ETO homologues
  • complex containing the corepressor SIN3B, HDAC1, MORF4L1 and PHF12 plays important roles in regulation of transcription
    • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with MAD-MAX heterodimers by binding to MAD
  • interacting with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities
  • interacting with FOXK1/MNF, NCOR1 and SAP30
  • interaction with SDS3 enhances the interaction with HDAC1 to form a complex
  • interacting with MAD3, MAD4, MAEL, REST and SETDB1
  • interacting with HCFC1
  • FOXK1 interacts with SIN3A/SIN3B through the SID and SIN3A/SIN3B has an important role in the regulation of cell cycle kinetics of the myogenic progenitors cells population
  • SIN3B, together with other MYC regulatory members, maintain the steady-state level of MXD4, in part through inhibition of BIRC2-mediated degradation of MXD4
  • interaction between the transcriptional corepressor SIN3B and voltage-gated sodium channels modulates functional channel expression
  • SIN3B decreases MYC protein levels upon MYC deacetylation
  • SIN3B is a novel direct target of BMI1, and BMI1-driven repression of SIN3B is an essential regulator of cellular senescence
  • BMP4-dependent transcription is negatively autoregulated in part by SIN3B alternative splicing, and RBM39 plays a role in this process
  • PHF12 associates with a chromatin interacting protein complex comprised of MORF4L1, SIN3B, and HDAC1, that functions as a transcriptional modulator
  • RNF220 is an E3 ligase promoting the ubiquitination and proteasomal degradation of SIN3B, a chromatin-associated protein, which plays a vital role in chromatin condensation
    • cell & other
    REGULATION
    Other ubiquitinated by RNF220
    strongly up-regulated upon oncogenic stress
    ASSOCIATED DISORDERS
    corresponding disease(s) IDASDCC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerendocrinepancreas
    has potential as a therapeutic target for inhibiting inflammation-driven tumorigenesis
    ANIMAL & CELL MODELS