Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ATRN contributors: mct - updated : 06-10-2017
HGNC name attractin
HGNC id 885
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • CUB domain
  • four plexin repeat
  • three EGF domains
  • two laminin EGF-like domain
  • C type lectin or carbohydrate recognition domain
  • HOMOLOGY
    interspecies homolog to murine Atrn
    Homologene
    FAMILY
  • CUB family
  • CATEGORY adhesion , signaling , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • in the cytoplasmic membrane of Golgi apparatus, endoplasmic reticulum, and mitochondria in neurons and glial cells
  • basic FUNCTION
  • regulator of immune cells interaction
  • regulator of body weight
  • TSPAN7 and ATRN are associated with spermatozoa
  • acted likely as a novel active substance and was involved in male reproduction
  • play a critical role in central myelination
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • agouti (in mouse)
  • melanocortin receptor
  • cell & other
  • T cell activator
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HLD14
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • suppression of obesity in mouse
  • age-related Atrn gene progressively loses its function and can cause testis vacuolation and impaired sperm function, which may be responsible for the impairment of male reproductive ability
  • Mahogunin ring finger-1 (Mgrn1) and Attractin (Atrn) null mutant mice accumulate vacuoles throughout the brain that appear very similar to those associated with prion disease