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FLASH GENE

Symbol

ATRN

contributors: mct - updated : 06-10-2017

HGNC name	attractin
HGNC id	885

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_139321 29 - 8658 NP_647537 158.5 1429 - 2000 10811918 attractin 1 skipping exon 25, including exons 26 to 30 NM_139322 25 - 4108 NP_647538 134 1272 - 2000 10811918 attractin 2 secreted form, ending in LINE-1 exon 25 attractin 3 - - 3894 - 1198 - 2000 10811918 ending in LINE-1 exon 25 NM_001323332 26 - 4339 NP_001310261 - 1289 - 2000 10811918 NM_001207047 25 - 3725 NP_001193976 - 1156 - 2000 10811918

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Homo sapiens   brain basal nuclei putamen     Rattus norvegicus   brain forebrain cerebral cortex     Rattus norvegicus   brain limbic system hippocampus     Rattus norvegicus   spinal cord         Rattus norvegicus Olfactory (smell) olfactory bulb         Rattus norvegicus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central gray matter     Rattus norvegicus

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic monocyte Homo sapiens Lymphoid/Immune activated B lymphocyte Nervous neuron Homo sapiens

cell lineage
cell lines
fluid/secretion	secreted form

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	CUB domain
	four plexin repeat
	three EGF domains
	two laminin EGF-like domain
	C type lectin or carbohydrate recognition domain

HOMOLOGY

interspecies

homolog to murine Atrn

Homologene

FAMILY

CUB family

CATEGORY

adhesion , signaling , receptor

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm
text	in the cytoplasmic membrane of Golgi apparatus, endoplasmic reticulum, and mitochondria in neurons and glial cells

basic FUNCTION	regulator of immune cells interaction
	regulator of body weight
	TSPAN7 and ATRN are associated with spermatozoa
	acted likely as a novel active substance and was involved in male reproduction
	play a critical role in central myelination

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	agouti (in mouse)
	melanocortin receptor

cell & other

T cell activator

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

HLD14

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	suppression of obesity in mouse
	age-related Atrn gene progressively loses its function and can cause testis vacuolation and impaired sperm function, which may be responsible for the impairment of male reproductive ability
	Mahogunin ring finger-1 (Mgrn1) and Attractin (Atrn) null mutant mice accumulate vacuoles throughout the brain that appear very similar to those associated with prion disease