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FLASH GENE
Symbol ATRN contributors: mct - updated : 06-10-2017
HGNC name attractin
HGNC id 885
Corresponding disease
HLD14 leukodystrophy, hypomyelinating 14
Location 20p13      Physical location : 3.451.664 - 3.631.769
Synonym name
  • soluble human plasma protein with dipeptidylpeptidase IV activity
  • mahogany protein
  • Synonym symbol(s) KIAA0548, MGCA, DPPTL, DPPT-L, MGC126754
    DNA
    TYPE functioning gene
    STRUCTURE 180.10 kb     29 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence   long interspersed repetitive elements
    text structure 25 exons (soluble forms) plus five 3' exons splicing over the LINE-1 element
    MAPPING cloned Y linked N status provisional
    Map pter - D20S113 - SNRPB /TGM3 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    29 - 8658 158.5 1429 - 2000 10811918
  • attractin 1
  • skipping exon 25, including exons 26 to 30
  • 25 - 4108 134 1272 - 2000 10811918
  • attractin 2
  • secreted form, ending in LINE-1 exon 25
  • - - 3894 - 1198 - 2000 10811918
    ending in LINE-1 exon 25
    26 - 4339 - 1289 - 2000 10811918
    25 - 3725 - 1156 - 2000 10811918
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly Homo sapiens
     brainbasal nucleiputamen   Rattus norvegicus
     brainforebraincerebral cortex   Rattus norvegicus
     brainlimbic systemhippocampus   Rattus norvegicus
     spinal cord     Rattus norvegicus
    Olfactory (smell)olfactory bulb     Rattus norvegicus
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentralgray matter   Rattus norvegicus
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte Homo sapiens
    Lymphoid/Immuneactivated B lymphocyte
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion secreted form
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • CUB domain
  • four plexin repeat
  • three EGF domains
  • two laminin EGF-like domain
  • C type lectin or carbohydrate recognition domain
  • HOMOLOGY
    interspecies homolog to murine Atrn
    Homologene
    FAMILY
  • CUB family
  • CATEGORY adhesion , signaling , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • in the cytoplasmic membrane of Golgi apparatus, endoplasmic reticulum, and mitochondria in neurons and glial cells
  • basic FUNCTION
  • regulator of immune cells interaction
  • regulator of body weight
  • TSPAN7 and ATRN are associated with spermatozoa
  • acted likely as a novel active substance and was involved in male reproduction
  • play a critical role in central myelination
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • agouti (in mouse)
  • melanocortin receptor
  • cell & other
  • T cell activator
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HLD14
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • suppression of obesity in mouse
  • age-related Atrn gene progressively loses its function and can cause testis vacuolation and impaired sperm function, which may be responsible for the impairment of male reproductive ability
  • Mahogunin ring finger-1 (Mgrn1) and Attractin (Atrn) null mutant mice accumulate vacuoles throughout the brain that appear very similar to those associated with prion disease