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FLASH GENE
Symbol B3GAT1 contributors: mct - updated : 01-12-2015
HGNC name beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
HGNC id 921
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a short cytoplasmic N terminal tail,
  • a hydrophobic transmembrane segment (TM1)
  • a proline rich region
  • a large C terminal catalytic domain with four highly conserved motifs and three potential N glycosylation sites
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Glcatp
    Homologene
    FAMILY glucuronyltransferase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II transmembrane protein
    basic FUNCTION
  • key enzyme in the synthesis of HNK-1 carbohydrate epitope on both glycoproteins and glycolipids
  • carbohydrate required for the structural and functional development of the mammalian nervous system, such as the maturation of dendritic spines and the acquisition of synaptic plasticity, respectively
  • mutual catalytic domains of B3GAT1 or B3GAT2 and CHST10 are important and sufficient for formation of an enzyme complex
  • is involved in synaptic plasticity and memory formation
  • highly expressed in the nervous system and is involved in synaptic plasticity and dendritic spine maturation
  • specific enzyme complex of B4GALT2 with B3GAT1 plays an important role in the biosynthesis of B3GAT1 carbohydrate
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physical and functional association of glucuronyltransferases and sulfotransferase involved in B3GAT1 biosynthesis
  • on GRIA2 regulates cell surface stability of GRIA2 by modulating the interaction with CDH2
  • CHST10 is a sulfotransferase that forms B3GAT1 glycan on neural cell adhesion proteins and glycolipids, and B3GAT1 is thought to modulate cell adhesion and possibly metastasis
  • novel role for CHST10 as a regulator of the functional glycans on DAG1 other than B3GAT1 biosynthesis
  • CHST10 adds sulfate to glucuronic acid to form a carbohydrate antigen, B3GAT1, in glycoproteins and glycolipids
  • KL expression was associated with expression of the non-sulfated B3GAT1 epitope
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS