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FLASH GENE

Symbol

B3GAT1

contributors: mct - updated : 01-12-2015

HGNC name	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
HGNC id	921

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q25      Physical location : 134.248.399 - 134.281.812
Genatlas name	human natural killer-1
Synonym name	leukocyte antigen 7
	cell differentiation antigen CD57, identified by monoclonal antibodies Leu7, L183, L187
	UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase
	glucuronosyltransferase P
Synonym symbol(s)	GLCATP, CD57, GlcAT-P, GlcUAT-P, HNK-1, HNK1, LEU7, NK-1, NK1
EC.number	2.4.1.135

DNA

TYPE	like-sequence
STRUCTURE	33.48 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018644 7 splicing 3534 NP_061114 37 334 - 2002 11788581 unique 5' and u'utr NM_054025 6 splicing 3666 NP_473366 37 334 - 2002 11788581 unique 5' and u'utr

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       lowly Nervous brain       predominantly Homo sapiens   brain hindbrain cerebellum     Mus musculus   brain limbic system hippocampus     Mus musculus   spinal cord         Mus musculus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central     predominantly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a short cytoplasmic N terminal tail,
	a hydrophobic transmembrane segment (TM1)
	a proline rich region
	a large C terminal catalytic domain with four highly conserved motifs and three potential N glycosylation sites

conjugated

GlycoP

HOMOLOGY

interspecies

ortholog to rattus Glcatp

Homologene

FAMILY

glucuronyltransferase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	type II transmembrane protein

basic FUNCTION	key enzyme in the synthesis of HNK-1 carbohydrate epitope on both glycoproteins and glycolipids
	carbohydrate required for the structural and functional development of the mammalian nervous system, such as the maturation of dendritic spines and the acquisition of synaptic plasticity, respectively
	mutual catalytic domains of B3GAT1 or B3GAT2 and CHST10 are important and sufficient for formation of an enzyme complex
	is involved in synaptic plasticity and memory formation
	highly expressed in the nervous system and is involved in synaptic plasticity and dendritic spine maturation
	specific enzyme complex of B4GALT2 with B3GAT1 plays an important role in the biosynthesis of B3GAT1 carbohydrate

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	physical and functional association of glucuronyltransferases and sulfotransferase involved in B3GAT1 biosynthesis
	on GRIA2 regulates cell surface stability of GRIA2 by modulating the interaction with CDH2
	CHST10 is a sulfotransferase that forms B3GAT1 glycan on neural cell adhesion proteins and glycolipids, and B3GAT1 is thought to modulate cell adhesion and possibly metastasis
	novel role for CHST10 as a regulator of the functional glycans on DAG1 other than B3GAT1 biosynthesis
	CHST10 adds sulfate to glucuronic acid to form a carbohydrate antigen, B3GAT1, in glycoproteins and glycolipids
	KL expression was associated with expression of the non-sulfated B3GAT1 epitope

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS