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FLASH GENE
Symbol HMG20A contributors: mct - updated : 19-05-2016
HGNC name high-mobility group 20A
HGNC id 5001
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
two HMG box domains (conserved DNA binding domain)
mono polymer heteromer , dimer
HOMOLOGY
interspecies homolog to murine Hmg20a
intraspecies paralog to HMG20B
Homologene
FAMILY HMG box family
CATEGORY DNA associated , transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,chromatin/chromosome
basic FUNCTION
  • playing a role in the extension of neurite-type cytoplasmic processes in developing cells
  • its expression leads to the abrogation of REST-mediated transcriptional repression and the resultant activation of neuronal-specific genes
  • HMG-domain protein, having a key role in the initiation of neuronal differentiation, through recruitment of MLL
  • activates REST (RE-1 silencing transcription factor)-responsive genes, playing a key role in the initiation of neuronal differentiation
  • HMG20A can replace HMG20B and, therefore, they are mutually exclusive subunits of the complex
  • is essential for the mesenchymal phenotype
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • HMG20B is able to form heterodimers with its homologous protein HMG20A
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with REST
  • direct interaction of beta-dystrobrevin(DTNB) with the HMG20 proteins HMG20A and HMG20B, suggesting that DTNB may be involved in regulating chromatin dynamics, possibly playing a role in neuronal differentiation
  • interplay between HMG20B and HMG20A controls the activity of the KDM1A–RCOR2 complex during neuronal differentiation
  • HMG20A together with KDM1A are required for SNAI1-dependent repression of epithelial genes and for TGFB1-triggered EMT
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS