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FLASH GENE

Symbol

HMG20A

contributors: mct - updated : 19-05-2016

HGNC name	high-mobility group 20A
HGNC id	5001

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	64.95 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	see TM6SF1

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018200 11 - 4153 NP_060670 40.1 347 testis, heart, spleen highly 2000 10773667 HMGX1 NM_001304505 10 - 3972 NP_001291434 - 234 spleen, testis, leukocytes, brain 2000 10773667 NM_001304504 10 - 4060 NP_001291433 40.1 347 weak expression 2000 10773667

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver       highly Endocrine pancreas       highly Nervous brain           brain hindbrain cerebellum       spinal cord         Reproductive female system uterus         male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two HMG box domains (conserved DNA binding domain)

mono polymer

heteromer , dimer

HOMOLOGY

interspecies

homolog to murine Hmg20a

intraspecies

paralog to HMG20B

Homologene

FAMILY

HMG box family

CATEGORY

DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	playing a role in the extension of neurite-type cytoplasmic processes in developing cells
	its expression leads to the abrogation of REST-mediated transcriptional repression and the resultant activation of neuronal-specific genes
	HMG-domain protein, having a key role in the initiation of neuronal differentiation, through recruitment of MLL
	activates REST (RE-1 silencing transcription factor)-responsive genes, playing a key role in the initiation of neuronal differentiation
	HMG20A can replace HMG20B and, therefore, they are mutually exclusive subunits of the complex
	is essential for the mesenchymal phenotype

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

HMG20B is able to form heterodimers with its homologous protein HMG20A

INTERACTION

DNA

RNA

small molecule

protein	interacting with REST
	direct interaction of beta-dystrobrevin(DTNB) with the HMG20 proteins HMG20A and HMG20B, suggesting that DTNB may be involved in regulating chromatin dynamics, possibly playing a role in neuronal differentiation
	interplay between HMG20B and HMG20A controls the activity of the KDM1A–RCOR2 complex during neuronal differentiation
	HMG20A together with KDM1A are required for SNAI1-dependent repression of epithelial genes and for TGFB1-triggered EMT

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS