Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ARID3B contributors: mct - updated : 03-10-2011
HGNC name AT rich interactive domain 3B (BRIGHT- like)
HGNC id 14350
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • DNA binding protein containing one AT/rich interaction domain (ARD)
  • a REKLES domain found only in the ARID3 subfamily (ARID3A, ARID3B, and ARID3C), consisting of two subdomains: a modestly conserved N-terminal REKLESalpha and a highly conserved (among ARID3 orthologous proteins) C-terminal REKLESbeta, and regulating functional properties of the ARID3 DNA binding domain
    • HOMOLOGY
    interspecies homolog to Drosophila dead ringer
    homolog to murine Bright (B cell regulator of IgH transcription)
    intraspecies paralog to DRIL1
    Homologene
    FAMILY ARID (AT-Rich Interaction Domain) transcription family
    CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation possibly in chromatin structure modification
  • plays an essential role in the survival of neural crest during embryogenesis
  • seems to play a key role in the malignant transformation of neuroblastoma
  • involved in the regulation of cell motility and rearrangements that lead to apical ectodermal ridge maturation
  • ARID3A and ARID3B positively regulate immunoglobulin heavy chain gene (IgH) transcription by binding to AT-rich motifs within Matrix Associating Regions (MARs) residing within a subset of V(H) promoters
  • having ability to specifically bind to DNA and to self-associate via a second domain, REKLES
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker may serve not only as a marker of malignancy in neuroblastoma
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    potential target for cancer therapy of stage IV neuroblastoma for which there is currently no effective treatment available
    ANIMAL & CELL MODELS