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FLASH GENE

Symbol

ARID3B

contributors: mct - updated : 03-10-2011

HGNC name	AT rich interactive domain 3B (BRIGHT- like)
HGNC id	14350

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Nervous brain         Reproductive male system prostate       Visual eye retina         eye retina

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous optic nerve

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	DNA binding protein containing one AT/rich interaction domain (ARD)
	a REKLES domain found only in the ARID3 subfamily (ARID3A, ARID3B, and ARID3C), consisting of two subdomains: a modestly conserved N-terminal REKLESalpha and a highly conserved (among ARID3 orthologous proteins) C-terminal REKLESbeta, and regulating functional properties of the ARID3 DNA binding domain

HOMOLOGY

interspecies	homolog to Drosophila dead ringer
	homolog to murine Bright (B cell regulator of IgH transcription)

intraspecies

paralog to DRIL1

Homologene

FAMILY

ARID (AT-Rich Interaction Domain) transcription family

CATEGORY

regulatory , DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	playing a role in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation possibly in chromatin structure modification
	plays an essential role in the survival of neural crest during embryogenesis
	seems to play a key role in the malignant transformation of neuroblastoma
	involved in the regulation of cell motility and rearrangements that lead to apical ectodermal ridge maturation
	ARID3A and ARID3B positively regulate immunoglobulin heavy chain gene (IgH) transcription by binding to AT-rich motifs within Matrix Associating Regions (MARs) residing within a subset of V(H) promoters
	having ability to specifically bind to DNA and to self-associate via a second domain, REKLES

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may serve not only as a marker of malignancy in neuroblastoma
Therapy target
	System Type Disorder Pubmed cancer brain glioma/neuroblstoma potential target for cancer therapy of stage IV neuroblastoma for which there is currently no effective treatment available

ANIMAL & CELL MODELS