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FLASH GENE
Symbol ARID3B contributors: mct - updated : 03-10-2011
HGNC name AT rich interactive domain 3B (BRIGHT- like)
HGNC id 14350
Location 15q24.2      Physical location : 74.833.547 - 74.890.470
Synonym name
  • Drosophila dead ringer -like 2
  • bright and dead ringer homolog
  • dead ringer (Drosophila)-like 2 (bright and dead ringer)
    • Synonym symbol(s) BDP, DRIL2
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text component of a cluster of paralogous genes on chromosomes 15 and 19
    STRUCTURE 56.93 kb     9 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map see TM6SF1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 4253 - 560 - 1999 10446990
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Visualeyeretina   
     eyeretina   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousoptic nerve
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • DNA binding protein containing one AT/rich interaction domain (ARD)
  • a REKLES domain found only in the ARID3 subfamily (ARID3A, ARID3B, and ARID3C), consisting of two subdomains: a modestly conserved N-terminal REKLESalpha and a highly conserved (among ARID3 orthologous proteins) C-terminal REKLESbeta, and regulating functional properties of the ARID3 DNA binding domain
    • HOMOLOGY
    interspecies homolog to Drosophila dead ringer
    homolog to murine Bright (B cell regulator of IgH transcription)
    intraspecies paralog to DRIL1
    Homologene
    FAMILY ARID (AT-Rich Interaction Domain) transcription family
    CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation possibly in chromatin structure modification
  • plays an essential role in the survival of neural crest during embryogenesis
  • seems to play a key role in the malignant transformation of neuroblastoma
  • involved in the regulation of cell motility and rearrangements that lead to apical ectodermal ridge maturation
  • ARID3A and ARID3B positively regulate immunoglobulin heavy chain gene (IgH) transcription by binding to AT-rich motifs within Matrix Associating Regions (MARs) residing within a subset of V(H) promoters
  • having ability to specifically bind to DNA and to self-associate via a second domain, REKLES
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker may serve not only as a marker of malignancy in neuroblastoma
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    potential target for cancer therapy of stage IV neuroblastoma for which there is currently no effective treatment available
    ANIMAL & CELL MODELS