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FLASH GENE
Symbol FOXL1 contributors: mct/npt - updated : 07-11-2009
HGNC name forkhead box L1
HGNC id 3817
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
text arranged in tandem with FOXC2, FOXF1
STRUCTURE 3.19 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 3207 - 345 - Pierrou (1994)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text gastro-intestinal mesenchyme
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a forkhead (FH,winged helix) domain
  • two loops-wings on the C terminal side of helix-turn-helix homeo domain
    • HOMOLOGY
    interspecies homolog to Drosophila homeo forkhead
    ortholog to murine Fkh6
    Homologene
    FAMILY
  • HNF-3 forkhead family of transcriptional activator
    • CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • embryonic transcriptional regulator
  • promotes liver repair after bile-duct-ligation-induced liver injury through activation of the canonical WNT/beta-catenin pathway (Sackett 2009)
  • with FOXF1, are mediators of the Hh (endoderm) to mesoderm signaling pathway (Madison 2009)
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text embryonic development, essential for the development and differentiation of (gastric) parietal cells
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    fkh6-/- knockout mice