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FLASH GENE
Symbol PNPLA8 contributors: mct/npt - updated : 18-03-2009
HGNC name patatin-like phospholipase domain containing 8
HGNC id 28900
Location 7q31      Physical location : 108.112.070 - 108.166.638
Synonym name
  • IPLA2-gamma
  • phospholipase A2, group VI (cytosolic, calcium-independent)
  • intracellular membrane-associated calciuml independent phospholipase A2 gamma
  • Synonym symbol(s) IPLA2-2, IPLA2 (GAMMA), IPLA2G, IPLA22, PNPLA-gamma
    EC.number 3.1.1.5
    DNA
    TYPE functioning gene
    STRUCTURE 54.57 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D7S1409 - D7S2459 - DLD - PNPLA8 - D7S2648 - D7S2425 - D7S1861 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3548 88.35 782 - Kienesberger (2008)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver    
    Endocrinepancreas    
     parathyroid   highly
    Lymphoid/Immunethymus   highly
    Nervousbrain    
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a lipase consensus sequence Gly-Xaa-Ser-Xaa-Gly
  • several stretches surrounding the motif, homologous to those of the catalytic domain of cytosolic calcium-independent phospholipase A2 (iPLA(2))
  • HOMOLOGY
    Homologene
    FAMILY
  • patatin-like phospholipase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,peroxisome
    text a 63-kDa form was localized mainly in peroxisomes (Murakami 2005)
    basic FUNCTION
  • may be contributing to lipid second messenger generation by hydrolysis of peroxisomal arachidonic acid-containing phospholipids
  • playing a role in the regulation of adipocyte differentiation (Wilson 2006)
  • having a role in cellular homeostasis and signaling, a functional link between peroxisomal AA release and eicosanoid generation, and a potential contribution to tumorigenesis (Murakami 2005)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    fatty acid metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS