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FLASH GENE
Symbol KCND3 contributors: mct - updated : 27-08-2014
HGNC name potassium voltage-gated channel, Shal-related subfamily, member 3
HGNC id 6239
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an intracellular N and C termini
  • six transmembrane segments (6TM)
  • a pore region between S5 and S6
  • a phosphorylation site on exon 5
  • a probably voltage-sensor S4 segment
    • mono polymer complex
    HOMOLOGY
    interspecies homolog to dog KCND3 (98.78 pc)
    homolog to chimpanzee KCND3 (97.56 pc)
    homolog to chicken KCND3 (94.96 pc)
    homolog to rattus Kcnd3 (99.06 pc)
    homolog to murine Kcnd3 (99.39 pc)
    Homologene
    FAMILY
  • potassium channel family
  • D (Shal) subfamily
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in setting the frequency of neuronal firing and heart pacing
  • initial phase of repolarization and setting the plateau voltage of the ventricular actin potential
  • inhibiting expression of Shaw channels
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cardiovascular
    PATHWAY
    metabolism
    signaling
    a component alpha subunit underlying I (TD) (transient outward) K+ current
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with KCNE1, KCNE2, SCN1B and KCNAB1
    • cell & other
    REGULATION
    inhibited by by estrogen
    KCNE3 by reducing the KCND3 current amplitude and slowing down the channel activation and inactivation
    Other modulated by STX1A
    ASSOCIATED DISORDERS
    corresponding disease(s) SCA19 , BRGS9
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    dog