| basic FUNCTION
| involved in respiratory chain biogenis |
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may be functioning in nitrogen fixation |
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implicated in cellular iron-sulfur cluster biosynthesis  |
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functionally competent reducing agent for cysteinyl persulfide bond cleavage, releasing inorganic sulfide for incorporation into the ISU-bound [2Fe-2S] cluster, a reactivity that might be facilitated by the flexibility of the C-terminal domain |
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play essential roles in the production of [Fe-S] centers for the normal maturation of lipoate-containing 2-oxoacid dehydrogenases, and for the assembly of the respiratory chain complexes |
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NFU1- (and BOLA3-) dependent assembled clusters are directed to complex I and lipoate synthesis |
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could function as an alternate scaffold to ISCU for assembly of [Fe-S] proteins, thus providing parallel pathways |
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functions as a late-acting maturation factor for a subset of mitochondrial Fe-S proteins |
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role of mitochondrial NFU1 late in the Fe-S protein biogenesis pathway is similar to the assumed function of the mitochondrial P loop NTPase IND1, which also transiently binds an Fe-S cluster and is specifically required for assembly of respiratory complex I |
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is a mitochondrial iron-sulfur scaffold protein, involved in iron-sulfur assembly and transfer to complex II and LAS (lipoic acid synthase) |
