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FLASH GENE
Symbol ADA2 contributors: mct - updated : 08-01-2019
HGNC name adenosine deaminase 2
HGNC id 1839
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal hydrophobic region
  • a catalytic C terminal domain
    • HOMOLOGY
    interspecies homolog to zebrafish cecr1
    Homologene
    FAMILY
  • adenosine and AMP deaminases family
  • ADGF subfamily
    • CATEGORY enzyme , signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • acting as a growth factor, having an adenosine deaminase activity
  • is essential for the endothelial integrity of small vessels
  • may likely act as a regulator of neutrophil activation, and that a reduction of ADA2 activity results in significant endothelial damage via a neutrophil-driven process
  • is a secreted growth factor that is important for the development and differentiation of hematopoietic and endothelial cells and maintenance of vascular integrity
  • ADA2 function in (M2-like) macrophages mediates cross talk between macrophages and pericytes in glioblastoma multiforme, GBM, via paracrine PDGFB-PDGFRB signaling, promoting pericyte recruitment and migration, and tumor angiogenesis
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other glycosylation at N127 is required for trafficking of ADA2
    from the ER to the Golgi apparatus
    ASSOCIATED DISORDERS
    corresponding disease(s) CES , DBAL1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in human retinas with diabetes
    Susceptibility
    Variant & Polymorphism
    Candidate gene cat eye syndrome (CES)
    Marker
    Therapy target
    ANIMAL & CELL MODELS