Selected-GenAtlas references SOURCE GeneCards NCBI Gene Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ADA2 contributors: mct - updated : 08-01-2019
HGNC name adenosine deaminase 2
HGNC id 1839
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver    
Respiratorylung    
Urinarykidney    
cell lineage lymphoblasts
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text lung, placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal hydrophobic region
  • a catalytic C terminal domain
    • HOMOLOGY
    interspecies homolog to zebrafish cecr1
    Homologene
    FAMILY
  • adenosine and AMP deaminases family
  • ADGF subfamily
    • CATEGORY enzyme , signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • acting as a growth factor, having an adenosine deaminase activity
  • is essential for the endothelial integrity of small vessels
  • may likely act as a regulator of neutrophil activation, and that a reduction of ADA2 activity results in significant endothelial damage via a neutrophil-driven process
  • is a secreted growth factor that is important for the development and differentiation of hematopoietic and endothelial cells and maintenance of vascular integrity
  • ADA2 function in (M2-like) macrophages mediates cross talk between macrophages and pericytes in glioblastoma multiforme, GBM, via paracrine PDGFB-PDGFRB signaling, promoting pericyte recruitment and migration, and tumor angiogenesis
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other glycosylation at N127 is required for trafficking of ADA2
    from the ER to the Golgi apparatus
    ASSOCIATED DISORDERS
    corresponding disease(s) CES , DBAL1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in human retinas with diabetes
    Susceptibility
    Variant & Polymorphism
    Candidate gene cat eye syndrome (CES)
    Marker
    Therapy target
    ANIMAL & CELL MODELS